Endocrine Abstracts

Within the adrenal gland, chromaffin cells and their progenitors are exposed to a wide variety of growth factors and hormones, including adrenal androgens such as DHEA. The DHEA producing-zona reticularis of the adrenal cortex is in close proximity to the neural crest-derived catecholamine-producing chromaffin cells of the medulla, enabling strong paracrine interactions. In vivo studies in humans revealed that congenital adrenal hyperplasia due to 21-hydroxylase ...

Chromaffin cells from adrenal medulla are the main source of epinephrine and norepinephrine hormones which are known to mediate so called fight-or-flight response to multiple environmental stress conditions. Chromaffin cells together with sympathetic neurons share the same sympathoadrenal cell lineage, but in contrast to neurons they maintain their proliferation during whole life span. However, little is known about chromaffin cells regeneration in an adult adrenal medulla.</p...

Neural cells are isolated from forebrain of 14.5 days old mouse embryos. In selective conditions these cells cluster forming sphere-like structures – neurospheres (NSCs). NSCs are heterogeneous structures containing only 2–5% of stem cells and progenitors being reportedly capable to transdifferentiate. Initially, aim of this study is to establish optimal culture conditions prior to investigation of transdifferentiation capacity of transplanted NSCs in kidney and adre...